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KMID : 0355620200460030197
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Journal of Korean Association of Oral and Maxillofacial Surgeons
2020 Volume.46 No. 3 p.197 ~ p.203
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FK506 immunosuppression for submandibular salivary gland allotransplantation in rabbit
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Almansoori Akram Abdo
Khentii Namuun
Ju Kyung-Won
Kim Bong-Jun
Kim Soung-Min
Lee Jong-Ho
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Abstract
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Objectives: We compared the outcomes of two different doses of FK506 (tacrolimus) for immunosuppression in submandibular salivary gland (SMG) allotransplantation.
Materials and Methods: Three SMG allotransplantation groups were established (n=6 per group) as follows: allograft rejection control (Allo-Ctrl), low dose (0.08 mg/kg) of FK506 (FK506-L), and high dose (0.16 mg/kg) of FK506 (FK506-H). Allograft survival and rejection were assessed by clinical observation, interleukin-2 levels as determined by enzyme-linked immunosorbent assay, blood sampling for complete blood count (CBC), and histological evaluation.
Results: Body weight and anorexia were higher in the FK506-H group but without a significant difference compared with the FK506-L population. CBC revealed a non-significantly reduced number of changes in the FK506-L group. Four glands in the FK506-H group and two glands in the FK506-L group were viable and functioning post-transplantation.
Conclusion: The survival rate of allotransplanted glands was higher in conjunction with the high dose of 0.16 mg/kg of FK506, with no major differ-ence in the side-effect profile when compared with the low dose of 0.08 mg/kg short-term outcomes.
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KEYWORD
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Submandibular salivary gland, Allotransplantation, Immunosuppression, FK506, Tacrolimus
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